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Crossopteryx is a monotypic genus of flowering plants in the Rubiaceae family. The genus contains only one species, viz. Crossopteryx febrifuga, which is found . Crossopteryx febrifuga. Rubiaceae. (G. Don.) Benth. Crossopteryx febrifuga (Paul Latham). Crossopteryx febrifuga flower and fruit (Paul. Latham). Preparations of Crossopteryx febrifuga (Afzel.) Benth. (Rubiaceae) are widely used in Northern Nigeria in the therapeutic management of.

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Histopathological studies further confirmed the extract’s mucosal protective effect in that it inhibited both piroxicam – and ethanol induced mucosal atrophy, infilteration by eosinophils and lymphoplasma cells in the wall glandular destruction, focal infiltration of inflammatory cells into mucosa areas.

In northern Nigeria, the plant has been used for treatment of pain and malaria for many years and its efficacy has been established in our laboratory Salawu et al. Stimulation of rat gastric mucosal leukotriene C4 formation by ethanol and effect of gastric protective crossopterxy. In the first phase of the oral acute toxicity study, no remarkable signs of toxicity were observed in the rats. The products of the 5-lipoxygenase pathway may also play a key role in the development of ulcer induced by irritant agents such as ethanol Lange et al.

The studies were carried out following fenrifuga principles of good laboratory practice and animal handling National Institutes of Health Guide for the Care and use for Laboratory animals; Publication No. These were then examined by a consultant histopathologist. Preparations of the tree is used traditionally for symptomatic relief of dry cough and for treatment of febrifhga wounds, respiratory infections, fever, dysentery and pain.

The number of deaths in each group within 24 h was recorded and the final LD 50 values febrifgua calculated as crosssopteryx geometric mean of the highest nonlethal dose with no deaths and the lowest lethal dose where deaths occurred.


Anti-ulcer action of Panax japonicus rhizome. Flavonoids have attracted the attention of many researchers because of their wide range of biological activities Lewis and Hanson,including antiulcer properties La Casa et al.

The stem bark was cleaned, air-dried for seven 7 febeifuga and crushed into coarse powder using a pestle and mortar.

West African Plants

Ethanol-induced gastric ulceration The method described by Salawu et al. Group 1 rats served as the normal control received no treatment. Table 2 Effect of the Crossopteryx febrifuga extract on piroxicam-induced gastric ulceration. The resultant mixture was filtered using Whatman filter paper No.

Assessing African medicinal plants for efficacy and safety: Oleanolic acid promotes healing of acetic acid-induced chronic gastric lesions in rats. Ethanol caused destruction of several glandular areas and focal infiltration of inflammatory cells into the sub mucosa areas. Open in a separate window. The method described by Salawu et al. These rats were also observed for signs of toxicity and mortality for the first critical 4h and thereafter daily for 7 days.

The ulcer lesions were scored according to severity Larach and Malagelada, as follows:. Drugs that are effective against peptic ulcer act either by reducing the aggressive factors on the gastro-duodenal mucosa or by increasing mucosal resistance against them Larach and Malagelada,Salawu et al.

Six hours after piroxicam administration, the rats in all the groups were sacrificed under diethyl ether anesthesia. The data obtained in the test for acute toxicity suggest that the extract is moderately toxic Salawu et al. One hour after ethanol administration, the rats were sacrificed under diethyl ether anaesthesia. The stomachs were removed, opened along the greater curvature, rinsed with slow running water.

Extensive mucosal atrophy noted, moderate infiltration by eosinophils and lymphoplasma cells of the wall. The ulcer lesions were scored according to severity Larach and Malagelada, as follows: The efficacy of the gastro-histoprotective effects of methanolic extract of Crossopteryx febrifuga against the piroxicam – induced gastric mucosa atrophy and ethanol-induced focal infiltration of inflammatory cells into mucosa areas, were comparable to that of misoprostol and cimetidine respectively.


Effect of Crossopteryx febrifuga on ethanol-induced gastric ulceration in rats. Preparation of the plant extract The stem bark was cleaned, air-dried for seven 7 days and crushed into coarse powder using a pestle and mortar. A severe decrease in gastric mucosal blood flow has been reported after treatment with indomethacin Murai et al.

Considering its widespread use in traditional medicine for the management of pain and inflammatory disorders such as arthritis, the need to investigate its safety on the gastrointestinal tract cannot be over emphasized. Antiulcerogenic activity of aescine in different experimental models.

Indian J Physiol Pharmacol. This observation further highlights the safety of the extract as an analgesic without gastrointestinal side effects associated with the traditional NSAIDs.

Gastro-Protective Effect of Crossopteryx Febrifuga in Wistar Rats

These were then processed routinely and the tissues were embedded in paraffin wax. The authors are grateful to the management of National Institute for Pharmaceutical Research and Development for provision of enabling environment and facilities used for the study. Rubiaceae are widely used in Crossoptegyx Nigeria in the therapeutic management of trypanosomiasis, malaria and painful inflammatory disorders.

Evidence for protective and antioxidant properties of rutin, a natural flavone, against ethanol induced gastric lesions.